Scientific publications
Effect Of Nutrient Synergy on Human Osteosarcoma Cells U-2OS
M.Waheed Roomi, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki
Antitumor Effect of an anti-cancer nutrient synergy in Pancreatic Cancer Cell Line MIA Pa Ca-2
M.W. Roomi, V. Ivanov, M. Rath, and A. Niedzwiecki
A Specific Combination Of Ascorbic Acid, Lysine, Proline And Epigallocatechin Gallate Inhibits Proliferation And Extracellular Matrix Invasion Of Various Human Cancer Cell Lines
Shrirang P Netke, M Waheed Roomi, Vadim Ivanov, Aleksandra Niedzwiecki* and Matthias Rath
Matthias Rath, Inc., Research and Development, Santa Clara, CA 95054
Cytotxic Effect of Lipophlic Substitution at 2-, 6-, and 2,6-Positions in Ascorbic Acid and Expression of Matrix Metalloproteinases in Hep G2 Cells, Melanoma Cells and Norman Human Dermal Fibroblast.
M.W. Roomi, S. Netke, V. Ivanov, A. Niedzwiecki and M. Rath
J. Am. Coll. Nutr. 20: 43, 2001
Inhibitory effects of ascorbic acid, proline and lysine supplementation on Matrigel invasion by human breast cancer cells, MDA-MB231.
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D .
Presented at: 19th Annual Miami Breast Cancer Conference, Miami Beach, Florida, February 27 – March 3, 2002. Published in: Conference Proceedings
Cellular Medicine Research Breakthroughs in the Control of Diseases: Report on Scientific Research
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D.
Presented at: 21st Century Medical Advances in the Treatment of Cancer and Aging, Miami , Fl, March 22-24, 2003; Published in: Conference Proceedings
A randomized, double-blind placebo-controlled clinical study documents the benefits of a vitamin program as an adjunct therapy in patients with paraxysmal atrial arrhytmia.
Matthias Rath M.D. and Aleksandra Niedzwiecki Ph.D.
14th Madrid Arrhytmia Meeting, Madrid, Spain, February 27-28, 2003
Nutritional supplement program halts progression of early coronary atherosclerosis.
M. Rath, M.D.
Controversies in Cardiovascular Nutrition, Stanford University Medical Center, Stanford, CA, May 4, 2002
Metastatic and Cytotoxic Effects of Ascorbigen and iso-Ascorbigen in Human Cancer Cell Lines.
M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath,
J. Am. Coll. Nut. 21: 54, 2002
Matrix Metalloproteinase-2 Inhibition and Invasion Potential in Human Chondrocytes by a natural anti-cancer formula - a Specific Mixture of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: American Association of Cancer Research Special Conference in Cancer Research: Proteases, Extracellular Matrix and Cancer, Hilton Head Island, South Carolina, Oct 9-13, 2002.
A Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine,Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human Cancer Cell Lines.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: European Organization for Research and Treatment of Cancer (EORTC), AACR and NCI Symposium on Molecular Targets and Cancer Therapeutics, Frankfurt, Germany, Nov 19-22, 2002; Published in: European Cancer Journal, 38, Suppl.7/Abs.280, 2002
Antitumorigenic Activity of a Natural Anti-Cancer Formula in Human Breast Cancer Lines MDA-MB-231 and MCF-7.
Roomi, M.W., Ivanov, V., Rath, M. and Niedzwiecki, A.
Presented at: The 8th Annual Multidisciplinary Symposium on Breast Disease, Amelia Island, FL, February 13-16, 2003; Published in: Conference Proceedings
A randomized, double-blind placebo-controlled clinical study documents the benefits of a vitamin program as an adjunct therapy in patients with paraxysmal atrial arrhytmia.
Matthias Rath M.D. and Aleksandra Niedzwiecki Ph.D.
14th Madrid Arrhytmia Meeting, Madrid, Spain, February 27-28, 2003
A novel in vitro bioassay for screening matrix metalloproteinases activity in human cancer cell lines
M Waheed Roomi, Shirang P Netke, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki
Proceedings of the American Association for Cancer Research 44:4559(2003)
Inhibitory Effect of a Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate on the Matrix Metalloproteinases Activities and Invasion of Human Fibrosarcoma HT-1080 Cells
MW Roomi, V Ivanov, SP Netke, M Rath and A Niedzwiecki
FASEB Journal (2003) 8452
Letter to Editor: Antioxidant supplements and simvastatin-niacin therapy.
Netke S, Ivanov V, Roomi W, Niedzwiecki A, Rath M.
Arterioscler Thromb Vasc Biol. (2001) 21, 2099-2100.
Transforming Growth Factor-Beta 1 and Ascorbate Regulate Proliferation of Cultured Smooth Muscle Cells by Independent Mechanisms
V. Ivanov, A.B. Rabovsky, S.V. Ivanova, A. Niedzwiecki
Atherosclerosis 140, 25-34 (1998)
Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives.
Cancer Lett 1998 Jan 9;122(1-2):93-9
Roomi MW; House D; Eckert-Maksic M; Maksic ZB; Tsao CS
Cytotoxic effect of substitution at 2-, 6-, and 2,6-positions in ascorbic acid on malignant cell line.
Cancer Biochem Biophys 1998 Nov;16(4):295-300
Roomi MW; House D; Tsao CS
Modulation of drug metabolizing enzymes in guinea pig liver by high intakes of ascorbic acid.
Int J Vitam Nutr Res 1998;68(1):42-7
Roomi MW; Netke S; Tsao C
Association between hyperlipidemia and hepatic cytochrome P-450 in guinea pigs.
Res Commun Mol Pathol Pharmacol 1997 Aug;97(2):139-50
Roomi MW
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Xenobiotica 1997 Sep;27(9):951-60
Roomi MW; Farber E; Parke DV
Ascorbic acid deficiency decreases the expression of CYP4A1 in liver microsomes of guinea pigs.
Res Commun Mol Pathol Pharmacol 1997 Jan;95(1):3-10
Roomi MW; Ogg M; Tsao CS; Gibson GG
Ascorbic Acid Protects Guinea Pigs from Acute Aflatoxin Toxicity
P. Netke, W. Roomi, C. Tsao, A. Niedzwiecki
, J. Toxicol. 143, 429-435. (1997)
Ascorbate Affects Proliferation of Guinea Pigs Vascular Smooth Muscle Cells by Direct and Extracellular Matrix Mediated Effects
V. O.Ivanov, S. Ivanova, A. Niedzwiecki
J.Mol.Cell.Cardiol. 29, 3293-3303 (1997)
Stress Induced Expression of Cu/Zn Superoxide Dismutase and Catalase in Senescent Drosophila melanogaster. in New Strategies in Prevention and Therapy.
J.E.Fleming, A. Niedzwiecki, I.Reveillaud
Biological Oxidants and Antioxidants., K. Schmidt (ed.), Hippokrates Verlag, Stuttgart, pp.181-192. (1994)
Mechanistic aspects of ascorbate inhibition of human immunodeficiency virus.
Chem Biol Interact 1994 Jun;91(2-3):207-15
Harakeh S; Niedzwiecki A; Jariwalla RJ
Heat shock induces changes in the expression and binding of ubiquitin in senescent Drosophila melanogaster
A. Niedzwiecki, J.E.Fleming
Dev. Genet., 14, 78-86. (1993)
Changes in Superoxide Dismutase and Catalase in Aging Heat-shocked Drosophila
A.Niedzwiecki, I.Reveillaud, J.E.Fleming
Free Rad. Res. Commun. 17, 355-367. (1992)
Role of oxidative stress in Drosophila aging.
J.E.Fleming, I.Reveillaud, A.Niedzwiecki
Mutat. Res. 275, 267-279 (1992)
Expression of Bovine Superoxide Dismutase in Drosophila.
Augments Resistance to Oxidative Stress
I.Reveillaud, A.Niedzwiecki, K.G.Bensch, J.E.Fleming .
Mol.Cell.Biol. 11, 1026-1030. (1991)
Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C.
Biochim Biophys Acta 1991 Nov 21;1097(4):283-8
Uhl J; Newton RC; Gross JL; Rommi W; Mochan E
Aging affects expression of 70-kDa heat shock proteins in Drosophila.
J Biol Chem 1991 May 15;266(14):9332-8
Niedzwiecki A; Kongpachith AM; Fleming JE
Lipoprotein (a) in the arterial wall
U. Beisiegel, A. Niendorf, K. Wolf, T. Reblin and M. Rath
EUROPEAN HEART JOURNAL (1990) 11 (SUPPL. E), 174-183
Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries
Axel Niendorf, Matthias Rath, Katrin Wolf, Susanne Peters, Hartmut Arps, Ulrike Beisiegel, and Manfred Dietel
Virchows Archives of Pathological Anatomy, 1990, Number 417, Pages 105-111
Detection and Quantification of Lipoprotein (a) in the Arterial Wall of 107 Coronary Bypass Patients
Matthias Rath, M.D., Axel Niendorf, Tjark Reblin, Manfred Dietel, Hans Joachim Krebber, and Ulrike Beisiegel
ARTERIOSCLEROSIS Vol 9 No 5, SEPTEMBER/OCTOBER 1989
Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect?
B. Finckh¹, A. Niendorf², M. Rath¹, and U. Beisiegel¹
EUR J CLIN PHARMACOL (1991) 40 [SUPPL 1]: S 77 - S 80
Lipoprotein (a) is a surrogate for ascorbate
Matthias Rath M.D. and Linus Pauling Ph.D.
PROCCEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA 1990, 87, 6204-6207
Kinetics of excretion of 2-acetylaminofluorene in normal and xenobiotic-treated rats and in rats with hepatocyte nodules.
Lab Invest 1989 Mar;60(3):399-408
Rinaudo JA; Eriksson LC; Roomi MW; Farber E
Modulation of the activity of hepatic gamma-glutamyl transpeptidase, adenosine triphosphatase, placental glutathione S-transferase and adenylate cyclase by acute administration of lead nitrate.
Basic Appl Histochem 1988;32(4):501-10
Columbano A; Ledda-Columbano GM; Ennas MG; Curto M; De Montis MG; Roomi MW; Pani P; Sarma DS
Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas.
Cancer Lett 1988 Dec 1;43(1-2):55-8
Roomi MW; Vincent SH; Farber E; Muller-Eberhard U
The galactosyltransferase activity of hepatic nodules during rat liver carcinogenesis.
Cancer Lett 1988 Dec 1;43(1-2):49-54
Roomi MW; Mitranic MM; Farber E; Moscarello MA
Glutathione and enzymes related to free radical metabolism in liver of rats fed a choline-devoid low-methionine diet.
Cancer Lett 1988 Jul;41(1):53-62
Ghoshal A; Roomi MW; Ahluwalia M; Simmonds W; Rushmore TH; Farber E; Ghoshal AK
Decreased expression of cytochrome P-452 in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis.
Biochem Biophys Res Commun 1988 Apr 29;152(2):921-5
Roomi MW; Bacher MA; Gibson GG; Parke DV; Farber E
Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
Matthias Rath M.D. and Linus Pauling Ph.D
Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate defiency, leading to the deposition of lipoprotein(a) and fibrinogen / fibrin in the vascular wall
Matthias Rath M.D. and Linus Pauling Ph.D.
Apoprotein (a) is an Adhesive Protein
Matthias Rath M.D. and Linus Pauling Ph.D.
Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of this Disease as a Cause for Human Mortality
Matthias Rath M.D. and Linus Pauling Ph.D.
Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs
Matthias Rath M.D. and Linus Pauling Ph.D.
Solution to the Puzzle of Human Evolution
Matthias Rath, M.D.
Journal of Orthomolecular Medicine, August 1992
Lipoprotein(a) Reduction by Ascorbate
Matthias Rath M.D. and Linus Pauling Ph.D.
Journal of Orthomolecular Medicine, August 1992
Reducing the Risk for Cardiovascular Disease with Nutritional Supplements
Matthias Rath, M.D.
A New Era in Medicine
Matthias Rath, M.D.
Puzzle of Human Evolution Solved
Matthias Rath, M.D.
PRESS RELEASE, Journal of Orthomolecular Medicine (November 1992)
Induction of the placental form of glutathione S-transferase by lead nitrate administration in rat liver.
Toxicol Pathol 1987;15(2):202-5
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS
Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase.
Biochem Biophys Res Commun 1987 Feb 27;143(1):98-103
Rushmore TH; Sharma RN; Roomi MW; Harris L; Satoh K; Sato K; Murray RK; Farber E
Lead nitrate induces certain biochemical properties characteristic of hepatocyte nodules.
Carcinogenesis 1986 Oct;7(10):1643-6
Roomi MW; Columbano A; Ledda-Columbano GM; Sarma DS
Changes in progesterone binding and metabolism in liver microsomes from persistent hepatocyte nodules and hepatomas in male rats.
Cancer Res 1986 Jan;46(1):76-80
Feuer G; Stuhne-Sekalec L; Roomi MW; Cameron RG
Association between progesterone binding and cytochrome P-450 content of hepatic microsomes in the rat treated with cobalt-haem.
Xenobiotica 1985 May;15(5):407-12
Feuer G; Waheed Roomi M; Stuhne-Sekalec L; Cameron RG
A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat.
Cancer Res 1985 Feb;45(2):564-71
Roomi MW; Ho RK; Sarma DS; Farber E
Chemical carcinogenesis: hepatocyte nodules with a special phenotype as a common step at the crossroads.
Toxicol Pathol 1984;12(3):288-90
Farber E; Eriksson LC; Roomi MW; Cameron RG; Hayes MA
Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen.
Toxicol Appl Pharmacol 1984 Oct;76(1):118-27
H ayes MA; Roberts E; Roomi MW; Safe SH; Farber E; Cameron RG
Orotic acid, a new promoter for experimental liver carcinogenesis.
Toxicol Pathol 1984;12(2):173-8
Rao PM; Nagamine Y; Roomi MW; Rajalakshmi S; Sarma DS
A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models.
Biochem Biophys Res Commun 1983 Dec 28;117(3):740-5
Eriksson LC; Sharma RN; Roomi MW; Ho RK; Farber E; Murray RK
Age-related changes in hepatic triacylglycerol content and phosphatidate phosphohydrolase activities in fasting male and female rats.
Enzyme 1983;30(1):59-65
Goldberg DM; Roomi MW; Yu A
Modulation by phenobarbital of lipolytic activity in postheparin plasma and tissues of the rat.
Can J Biochem 1982 Nov;60(11):1077-83
Goldberg DM; Roomi MW; Yu A
Effects of phenobarbital upon triacylglycerol metabolism in the guinea pig.
Can J Biochem 1981 Jan;59(1):48-53
Goldberg DM; Yu A; Roomi MW; Roncari DA
Enzyme induction and hepatic glycerolipid synthesis in rats treated with 3-methylcholanthrene.
Can J Biochem 1981 Sep;59(9):793-8
Goldberg DM; Roomi MW; Yu A; Roncari DA
The PO glycoprotein of peripheral nerve myelin.
Can J Biochem 1980 Oct;58(10):913-21
Ishaque A; Roomi MW; Szymanska I; Kowalski S; Eylar EH
Effects of phenobarbital upon triacylglycerol metabolism in the rabbit.
Biochem J 1980 Oct 15;192(1):165-75
Goldberg DM; Roomi MW; Yu A; Roncari DA
The action of trypsin on central and peripheral nerve myelin.
Adv Exp Med Biol 1978;100:307-28
Eylar EH; Roomi MW
The PO protein. The major glycoprotein of peripheral nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):112-21
Roomi MW; Ishaque A; Khan NR; Eylar EH
Isolation of a product from the trypsin-digested glycoprotein of sciatic nerve myelin.
Biochim Biophys Acta 1978 Sep 26;536(1):122-33
Roomi MW; Eylar EH
Porphyria-inducing activity of a series of pyridine and dihydropyridine compounds. Investigation in a cell culture system.
J Med Chem 1975 May;18(5):457-60
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