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"Tocopherol in Osteoarthritis: a controlled pilot study."
Machtey I; Ouaknine L; J Am Geriatr Soc 1978 Jul;26(7):328-30.
ABSTRACT: Thirty-two patients entered a simple-blind, cross-over study
on the action of tocopherol in osteoarthritis; only 3 did not complete
the course. Each patient was randomly assigned either to the tocopherol
group (600 mg/day for 10 days) or to the placebo group. After 10 days
the groups were transposed. The analgesic and other possible effects of
tocopherol vs. placebo were assessed by the patients' daily records, by
the physician's personal examination and interview, and by observations
on the use of an additionally permitted analgesic (pro re nata). In
52 percent of the 29 patients who completed the study of good tocopherol
analgesic effect was noted, but only 4 percent of those receiving
placebo reported a similar effect. The difference was statistically significant.
Further large-scale assessement of the influence of tocopherol in osteoarthritis
would seem to be justified.